Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors

Details Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors Fused pyrimidines as d-alanyl-d-alanine ligase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61L 2/16 (2006.01) A61P 31/04 (2006.01) C07D 401/12 (2006.01) C07D 471/04 (2006.01) C07D 475/08 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2451800

The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

La présente invention repose sur la découverte d'une nouvelle classe de composés hétérocycliques présentant par exemple des propriétés antibactériennes. L'enzyme de la ligase D-Ala-D-Ala est une enzyme du chemin de transit critique de la synthèse de la paroi cellulaire des bactéries. Les composés peuvent se lier à la ligase D-Ala-D-Ala de l'enzyme. L'activité des nouveaux composés combinée à leur aptitude à traverser les membranes des cellules bactériennes les rend aptes à l'utilisation comme médicaments antibactériens ou d'autres applications antibactériennes.

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