Fused pyrrolidino-cyclopropane derivatives as selective...

Details Fused pyrrolidino-cyclopropane derivatives as selective... Fused pyrrolidino-cyclopropane derivatives as selective...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/407 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2735286

The present invention relates to fused pyrrolidino-cyclopropane derivatives according to Formulae (I) to (II), as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1(11-.beta.- HSD-1 ) and the use of such compounds for the treatment and/or prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis/ cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.

Cette invention concerne des dérivés de la fusion pyrrolidino-cyclopropane selon les formules (I) à (ll), utilisés en tant quinhibiteurs sélectifs de lenzyme 11-bêta-hydroxystéroïde déshydrogénase de type 1 (11-ß-HSD-1 ) et lutilisation de ces composés dans le traitement et/ou la prévention du syndrome métabolique, du diabète, de linsulinorésistance, de lobésité, des troubles lipidiques, du glaucome, de lostéoporose, des troubles cognitifs, de lanxiété, de la dépression, des affections immunitaires, de lhypertension et dautres maladies et pathologies.

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