Fused pyrrolocarbazoles

Details Fused pyrrolocarbazoles Fused pyrrolocarbazoles

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/403 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01)

Patent

CA 2202487

Disclosed herein are compounds referred to as "fused pyrrolocarbazoles" which possess a variety of functional pharmacological activities including effect on the function and/or survival of trophic factor responsive cells; inhibition of enzymatic activity; inhibition of inflammation-associated responses; inhibition of cell growth associated with hyperproliferative states; and inhibition of developmentally programmed motoneuron death. The disclosed compounds are represented by the following general formula: (see formula I) Methodologies for the synthetic production of fused pyrrolocarbazoles are also disclosed, as well as exemplary uses of the compounds.

La présente invention concerne des composés appelés "Pyrrolocarbazoles fusionnés" qui possèdent une multiplicité d'activités fonctionnelles pharmacologiques, dont un effet, sur la fonction et/ou la survie des cellules réagissant au facteur trophique, l'inhibition de l'activité enzymatique, l'inhibition des réponses associées aux phénomènes inflammatoires, l'inhibition de la croissance cellulaire associée aux états hyperproliférants, et l'inhibition de la mort motoneuronale programmée par le développement. Les composés de la présente invention sont représentés par la formule générale (G). L'invention concerne également des procédés de production synthétique de pyrrolocarbazoles fusionnés ainsi que des exemples d'emploi de ces composés.

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