Fused-ring compounds and use thereof as drugs for hepatitis c

Details Fused-ring compounds and use thereof as drugs for hepatitis c Fused-ring compounds and use thereof as drugs for hepatitis c

C - Chemistry, Metallurgy

07

D

C07D 209/12 (2006.01) A61K 31/407 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/42 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/428 (2006.01) A61K 31/433 (2006.01) A61K 31/437 (2006.01) A61K 31/4439 (2006.01) A61K 31/4523 (2006.01) A61K 31/454 (2006.01) A61K 31/4709 (2006.01) A61K 31/4725 (2006.01) A61K 31/496 (2006.01) A61K 31/498 (2006.01) A61K 31/506 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A6

Patent

CA 2363274

Fused-ring compounds represented by general formula [I] or the like, or pharmaceutically acceptable salts thereof; and hepatitis C remedies containing the compounds or salts: [I] (wherein each symbol is as defined in the description). The above compounds and salts exhibit an anti-HCV (hepatitis C virus) activity by virtue of their inhibitory activity against HCV polymerase, thus being useful as therapeutic or preventive agents for hepatitis C.

L'invention concerne des composés à cycles accolés représentés par la formule générale (I), par exemple, ou des sels pharmaceutiquement acceptables desdits composés, ainsi que des remèdes contre l'hépatite C contenant ces composés ou ces sels. Dans cette formule, chaque symbole est tel que défini dans le descriptif. Les composés et les sels susmentionnés présentent une activité anti-VHC (virus de l'hépatite C) du fait de leur activité inhibitrice dirigée contre la polymérase VHC. Ils sont donc utiles en tant qu'agents thérapeutiques ou prophylactiques destinés à l'hépatite C.

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