Fused-ring derivative and medical application of same

Details Fused-ring derivative and medical application of same Fused-ring derivative and medical application of same

C - Chemistry, Metallurgy

07

D

C07D 213/79 (2006.01) A61K 31/192 (2006.01) A61K 31/415 (2006.01) A61K 31/426 (2006.01) A61K 31/44 (2006.01) A61K 31/47 (2006.01) A61P 3/00 (2006.01) A61P 13/04 (2006.01) A61P 13/12 (2006.01) A61P 19/00 (2006.01) A61P 19/06 (2006.01) C07C 255/57 (2006.01) C07D 215/50 (2006.01) C07D 231/14 (2006.01) C07D 277/20 (2006.01) C07D 277/56 (2006.01)

Patent

CA 2739060

The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to fused ring derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of plasma uric acid level, prodrugs thereof, salts thereof or the like. In the formula (I), X1 and X2 represent CH or N; ring U represents aryl or heteroaryl; m represents integral number from 0 to 2; n represents integral number from 0 to 3; R1 represents a hydroxy group, amino or C1-6 alkyl; R2 represents C1-6 alkyl, C1-6 alkoxy C1-6 alkyl or the like. (see formula I)

Provided is a compound that is useful for the prevention of and as a remedy for diseases attributable to abnormal plasma uric acid levels. The invention pertains to a fused-ring derivative represented by formula (I), and to prodrugs or salts thereof, which has xanthine oxidase inhibitory activity and is thus useful for the prevention of and as a remedy for diseases attributable to abnormal plasma uric acid levels. In formula (I), X1 and X2 are CH or N, ring U is an aryl or a heteroaryl, m is an integer of 0-2, n is an integer of 0-3, R1 is a hydroxyl group, an amino or a C1-6 alkyl, and R2 is a C1-6 alkyl, C1-6 alkoxy, C1-6 alkyl, etc.

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