Fused ring dicationic anti-protozoan agents and their prodrugs

C - Chemistry – Metallurgy – 07 – C

Patent

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Details

C07C 279/18 (2006.01) A01N 37/52 (2006.01) A01N 43/42 (2006.01) A61K 31/155 (2006.01) A61K 31/44 (2006.01) C07D 219/08 (2006.01)

Patent

CA 2547972

Novel fused ring dicationic anti-protozoan compounds. Representative protozoan species include but are not limited to Trypanosoma brucei rhodesiense (T.b.r) and Plasmodium faciparum. Prodrugs of these compounds can be used as an oral treatment for malaria and human African trypanosomiasis.

La présente invention concerne de nouveaux composés antiprotozoaires dicationiques cycliques fusionnés. Les espèces protozoaires représentatives comprennent, mais sans limitation, Trypanosoma brucei rhodesiense (T.b.r) et Plasmodium faciparum. Les promédicaments de ces composés peuvent être utilisés en tant que traitement oral contre la malaria et la trypanosomiase africaine humaine.

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