Fused-ring heterocycle opioids

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 221/26 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01) C07D 221/28 (2006.01) C07D 489/09 (2006.01) C07D 489/12 (2006.01)

Patent

CA 2686851

Compounds of formula (I) are disclosed. In these compounds (1) or (2) is a heterocyclic ring. The compounds are useful as analgesics, anti-pruritics, anti-diarrheal agents, anticonvulsants, antitussives, anorexics/antiobesity agents and as treatments for hyperalgesia, drug addiction, respiratory depression, dyskinesia, pain (including neuropathic pain), irritable bowel syndrome and gastrointestinal motility disorders.

L'invention concerne des composés de formule (I). Dans ces composés, (1) ou (2) est un cycle hétérocyclique. Les composés sont utiles en tant qu'analgésiques, antipruritiques, agents antidiarrhéiques, anticonvulsifs, antitussifs, agents anorexiques/anti-obésités et en tant que traitements pour l'hyperalgésie, la dépendance aux drogues, la dépression respiratoire, la dyskinésie, la douleur (y compris douleur neuropathique), le syndrome du côlon irritable et des troubles de la motilité gastro-intestinale.

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