Fused ring thrombin receptor antagonists

Details Fused ring thrombin receptor antagonists Fused ring thrombin receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/4439 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2650404

Fused-ring, heterocyclic-substituted tricyclics of the Formula (I) or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture wherein Formula (II) represents an optional double bond, and wherein An, En, Mn, Gn, Jn, R3, n7, R8, R9, R10, R11, R32, R33, X, Y, B and Het are herein defined and the remaining substituents are as defined in the specification, are disclosed, as well as pharmaceutical compositions containing them and a method of treating diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, and cancer by administering said compounds. Combination therapy with other cardiovascular agents is also claimed.

L'invention concerne des produits tricycliques substitués par des groupes hétérocycliques à noyaux fusionnés de la formule formule (I) ou un sel ou solvate pharmaceutiquement acceptable dudit composé, isomère ou mélange racémique où (II) représente une double liaison facultative, et où An, En, Mn, Gn, Jn, R3, n7, R8, R9, R10, R11, R32, R33, X, Y, B et Het sont définis ici et les substituants restants sont tels que définis dans la description, ainsi que des compositions pharmaceutiques les contenant et une méthode de traitement de maladies associées à la thrombose, l'athérosclérose, la resténose, l'hypertension, l'angine de poitrine, l'arythmie, l'insuffisance cardiaque et le cancer par administration desdits composés. Une thérapie de combinaison avec d'autres agents cardio-vasculaires est également revendiquée.

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