Fused thiazole derivatives as kinase inhibitors

Details Fused thiazole derivatives as kinase inhibitors Fused thiazole derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 513/04 (2006.01) A61K 31/437 (2006.01) A61K 31/519 (2006.01) C07D 513/12 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2692085

A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

L'invention porte sur une série de dérivés de 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one, qui sont substitués en position 2 par une fraction morpholine-4-yle substituée, étant des inhibiteurs sélectifs d'enzymes PI3 kinases. En conséquence, ces dérivés sont utiles en médecine, par exemple, dans le traitement d'états inflammatoires, auto-immuns, cardiovasculaires, neurodégénératifs, métaboliques, oncologiques, nociceptifs ou ophtalmiques.

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