Fused thiazole derivatives as kinase inhibitors

Details Fused thiazole derivatives as kinase inhibitors Fused thiazole derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 277/82 (2006.01) A61K 31/425 (2006.01) A61K 31/5377 (2006.01) A61K 31/55 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2607426

A series of 5,6-dihydro-l,3-benzothiazol-7(4H)-one derivatives, and analogues thereof, which are substituted in the 2-position by an optionally substituted morpholin-4-yl moiety, being selective inhibitors of PD kinase enzymes, are accordingly of b.enefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

L'invention concerne une série de dérivés de la 5,6-dihydro-l,3-benzothiazol-7(4H)-one, et leurs analogues, substitués en position 2 par un groupe morpholin-4-yle éventuellement substitué, agissant comme des inhibiteurs sélectifs des enzymes PD kinases, et utiles en médecine, par exemple pour le traitement de maladies inflammatoires, auto-immunes, cardiovasculaires, neurodégénératrices, métaboliques, oncologiques, nociceptives ou ophtalmiques.

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