Fused thieno [2, 3-b] pyridine and thiazolo [5, 4-b]...

Details Fused thieno [2, 3-b] pyridine and thiazolo [5, 4-b]... Fused thieno [2, 3-b] pyridine and thiazolo [5, 4-b]...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61K 31/4545 (2006.01) A61K 31/4709 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/498 (2006.01) A61K 31/53 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 495/14 (2006.01) C07D 495/20 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2599899

The present invention provides compounds of Formula (I) (wherein R1, R3, X, W, Z and ring Y are as defined herein). The present invention also provides compositions comprising these compounds that are useful for treating cellular proliferative diseases or disorders associated with KSP kinesin activity and for inhibiting KSP kinesin activity.

L'invention concerne des composés de formule (I) (dans laquelle R1, R3, X, W, Z et le cycle Y sont tels que définis dans la description). Cette invention concerne également des compositions comprenant ces composés, et servant à traiter des maladies liées à une prolifération cellulaire, ou des troubles qui sont associés à l'activité de la kinésine KSP, ainsi qu'à inhiber l'activité de cette kinésine KSP.

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