Fused thiophene derivatives, their production and use

Details Fused thiophene derivatives, their production and use Fused thiophene derivatives, their production and use

C - Chemistry, Metallurgy

07

D

167/211, 260/246

C07D 495/04 (2006.01) A61K 31/395 (2006.01)

Patent

CA 2036618

Novel fused thiophene derivatives of the formula (I): (see formula I) wherein W is (see formula II) or (see formula III) R1 and R2 are each. H, halogen, cyano, nitro, acylamino, or a hydrocarbon residue; R3 is H, optionally substituted alkyl or alkenyl, or -COD wherein D is H, alkoxy, hydroxy, halogen, or optionally substituted amino; R4 is H, halogen or nitro; R5 is a residue capable of forming or convertible into an anion; R6 is H or optionally substituted alkyl or alkenyl; R7 is a hydrocarbon residue; A is a bond or a spacer; and n is 1 or 2; have potent angiotensin II antagonist activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases.

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