Fused triazole derivatives as dipeptidyl peptidase-iv...

Details Fused triazole derivatives as dipeptidyl peptidase-iv... Fused triazole derivatives as dipeptidyl peptidase-iv...

C - Chemistry, Metallurgy

07

D

C07D 487/14 (2006.01) A61K 31/4985 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61P 3/00 (2006.01) C07D 471/14 (2006.01)

Patent

CA 2576465

The present invention is directed to novel fused triazole derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase- IV enzyme is involved.

La présente invention concerne de nouveaux dérivés de triazole accolés inhibiteurs de la dipeptidyl peptidase-IV ("inhibiteurs DPP-IV") et utilisés dans le traitement ou la prévention des maladies associées à la dipeptidyl peptidase-IV, telles que le diabète et, en particulier, le diabète de type 2. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, et l'utilisation de ces composés et compositions dans la prévention ou le traitement des maladies associées à la dipeptidyl peptidase-IV.

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