Fused tricyclic compounds as inhibitors of tumor necrosis...

Details Fused tricyclic compounds as inhibitors of tumor necrosis... Fused tricyclic compounds as inhibitors of tumor necrosis...

C - Chemistry, Metallurgy

07

D

C07D 327/02 (2006.01) A61K 31/39 (2006.01) C07D 411/04 (2006.01)

Patent

CA 2587671

Compounds of formula (1): are disclosed, wherein V is CH2; W is S(O)m; m is the integer 0, 1 or 2; U is O, C(O), CR13R14 or NR15; where R13 is H, alkyl; R14 is H, OH, OR13 or OCOR13; R15 is H, alkyl, cycloalkyl, alkenyl, C(O)R13, C(O)OR13 or alkylaminocarbonyl; R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein. These compounds are inhibitor of tumor necrosis factor-alpha (TNF- ) and are useful as medicaments for the treatment and prevention of disorders caused by increased TNF- activity, in particular inflammations.

L'invention concerne des composés de la formule 1, dans laquelle V représente CH2, W représente S(O)m; m représente un entier, soit 0, 1 ou 2; U représente O, C(O), CR13R14 or NR15 où R13 ou OCOR13; R15 représente H, alkyle, cycloalkyle, alcényle, C(O)OR13 ou alkyl aminocarbonyle; R1, R2, R3, R4, R5, R6, R7 et R8 sont tels que définis dans le descriptif. Ces composés sont des inhibiteurs du facteur de nécrose tumorale-alpha (TNF-); on les utilisent comme médicaments pour le traitement et la prévention de troubles provoqués par l'activité de TNF-, en particulier des inflammations.

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