Fused tricyclic mglur1 antagonists as therapeutic agents

Details Fused tricyclic mglur1 antagonists as therapeutic agents Fused tricyclic mglur1 antagonists as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2619362

In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluRI ) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

Dans de nombreux modes de réalisation, cette invention concerne des composés tricycliques de formule (I) (J1-J3, X, Z, et R1-R4 sont tels que définis dans cette formule) utiles en tant qu'antagonistes (mGluR) du récepteur de glutamate métabotropique, notamment en tant qu'antagonistes 1 du récepteur de glutamate métabotropique sélectif, des compositions pharmaceutiques contenant ces composés, et des procédés de traitement utilisant ces composés et des compositions destinés à traiter des maladies associées au récepteur de glutamate métabotropique (par exemple, mGluRI) telles que, par exemple, la douleur, la migraine, l'anxiété, l'incontinence urinaire et les maladies neurodégénératives, notamment la maladie d'Alzheimer.

Affiliated with

Also associated with

Rating

Fused tricyclic mglur1 antagonists as therapeutic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fused tricyclic mglur1 antagonists as therapeutic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fused tricyclic mglur1 antagonists as therapeutic agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1658721