Fused tricyclic mglur1 antagonists as therapeutic agents

Details Fused tricyclic mglur1 antagonists as therapeutic agents Fused tricyclic mglur1 antagonists as therapeutic agents

C - Chemistry, Metallurgy

07

D

C07D 495/14 (2006.01) A61P 13/00 (2006.01) A61P 25/00 (2006.01) A61P 25/04 (2006.01) A61P 25/06 (2006.01) A61P 25/22 (2006.01)

Patent

CA 2619419

In its many embodiments, the present invention provides tricyclic compounds of formula (I) (wherein J1-J3, X, Z, and R1, R3, and R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluR1) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.

L'invention porte dans ses différentes exécutions sur des composés tricycliques de formule (I) (dans laquelle: J1-J3, X, Z, et R1, R3, et R4 sont tels que définis dans la description), s'avérant utiles comme antagonistes du récepteur métabotropique du glutamate (mGluR), et en particulier comme antagonistes du récepteur métabotropique 1 du glutamate. L'invention porte également sur des préparations pharmaceutiques contenant lesdits composés, et sur des méthodes de traitement utilisant lesdits composés et des compositions traitant certaines maladies associées au récepteur métabotropique du glutamate (par exemple le mGluR1) telles que par exemple: la douleur, la migraine, l'anxiété, l'incontinence urinaire et des troubles neurodégénératifs tels que la maladie d'Alzheimer.

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