C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61K 31/4375 (2006.01) A61K 31/4745 (2006.01) A61K 31/519 (2006.01) A61P 25/00 (2006.01) C07D 471/14 (2006.01) C07D 513/14 (2006.01)
Patent
CA 2651550
The invention provides compounds of formula (I): or pharmaceutically salts thereof, where R1, R2 and the A, B, and C-rings are as defined herein. Compounds of formula (I) are useful in treating or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds or salts of formula (I), methods of preparing the desired compunds, and methods of treating cognitive disorders, such as Alzheimer's disease, using the compounds or salts of Formula (I).
La présente invention concerne des composés de formule I : ou des sels pharmaceutiquement acceptables de ceux-ci, où R1, R2 et les cycles A, B et C sont comme présentement défini. Les composés de formule I sont utiles dans le traitement ou la prévention de troubles cognitifs, tels que la maladie d'Alzheimer. L'invention concerne en outre des compositions pharmaceutiques comprenant des composés ou sels de formule I, des procédés de préparation des composés souhaités, et des procédés de traitement de troubles cognitifs, tels que la maladie d'Alzheimer, utilisant les composés ou sels de Formule(I).
Aubele Danielle L.
Garofalo Albert W.
Hom Roy
Konradi Andrei W.
Neitzel Martin L.
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
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