Fusion constructs and use of same to produce antibodies with...

Details Fusion constructs and use of same to produce antibodies with... Fusion constructs and use of same to produce antibodies with...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/32 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 9/24 (2006.01) C12N 15/12 (2006.01) C12N 15/54 (2006.01) C12N 15/56 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2513797

The present invention relates to the field of glycosylation engineering of proteins. More particularly, the present invention relates to nucleic acid molecules, including fusion constructs, having catalytic activity and the use of same in glycosylation engineering of host cells to generate polypeptides with improved therapeutic properties, including antibodies with increased Fc receptor binding and increased effector function.

L'invention concerne le domaine de la formation de protéines par glycosylation. En particulier, l'invention concerne des molécules d'acide nucléique, comprenant des constructions hybrides, présentant une activité catalytique, et l'utilisation de celles-ci dans la formation de cellules hôtes par glycosylation, pour générer des polypeptides présentant des propriétés thérapeutiques améliorées, notamment des anticorps présentant une liaison améliorée avec le récepteur Fc, et une fonction d'effecteur améliorée.

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