Fusion genes associated with acute megakaryoblastic leukemias

Details Fusion genes associated with acute megakaryoblastic leukemias Fusion genes associated with acute megakaryoblastic leukemias

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01K 67/027 (2006.01) C07K 16/18 (2006.01) C07K 19/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2445423

The invention relates to human nucleotide sequences which occur as a result of the t(1;22)(p13;q13) chromosomal translocation event which is known to occur almost invariable in young children with acute megakaryoblastic leukemia. The translocation results in the formation of fusion genes which encode fusion proteins. The invention provides the nucleotide sequences of transcripts of the fusion genes and the amino acid sequences of the fusion proteins encoded thereby. Also provided are methods for detecting the t(1, 22) translocation, for identifying agents capable of binding to the fusion protein and for identifying agents useful for treating patients with acute megakaryoblastic leukemia.

L'invention porte sur des séquences nucléotidiques humaines qui s'avèrent être le résultat de la translocation chromosomique t(1;22)(p13;q13) apparaissant presque invariablement chez de jeunes enfants atteints d'une leucémie aiguë mégacaryoblastique. La translocation entraîne la formation de gènes de fusion qui codent des protéines de fusion. L'invention porte également sur des séquences nucléotidiques de produits de transcription de gènes de fusion et sur les séquences d'acides aminés des protéines de fusion codées par les gènes. L'invention porte aussi sur des procédés de détection de la translocation t(1, 22) visant à identifier des agents capables de se lier aux protéines de fusion et d'agents utiles dans le traitement de patients atteints de leucémie aiguë mégacaryoblastique.

Affiliated with

Also associated with

Rating

Fusion genes associated with acute megakaryoblastic leukemias does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fusion genes associated with acute megakaryoblastic leukemias, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fusion genes associated with acute megakaryoblastic leukemias will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2073928