Fusion molecules and il-15 variants

Details Fusion molecules and il-15 variants Fusion molecules and il-15 variants

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 35/12 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 31/14 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12N 15/24 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2690825

The instant invention provides soluble fusion protein complexes and IL- 15 variants that have therapeutic and diagnostic use, and methods for making thesuch proteins. The instant invention additionally provides methods of stimulating or suppressing immune responses in a mammal using the fusion protein complexes and IL- 15 variants of the invention.

La présente invention concerne des complexes de protéines de fusion solubles et des variantes de IL-15 qui ont une utilisation thérapeutique et diagnostique, ainsi que des procédés de préparation de telles protéines. La présente invention concerne également des procédés de stimulation ou de suppression des réponses immunitaires chez un mammifère utilisant les complexes de protéines de fusion et les variantes de IL-15 selon l'invention.

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