C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) C12N 9/22 (2006.01) C12N 15/55 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2722797
Targeted transcriptional effectors (tran-scription activators and transcription repressors) derived from meganucleases are described. Also described are nu-cleic acids encoding same, and methods of using same to regulate gene expression. The targeted transcriptional ef-fectors can comprise (i) a meganuclease DNA-binding do-main lacking endonuclease cleavage activity that binds to a target recognition site; and (ii) a transcription effector do-main.
L'invention porte sur des effecteurs de transcription ciblés (activateurs et répresseurs de transcription) issus de méganucléases. L'invention porte également sur des acides nucléiques codant pour ceux-ci et sur des procédés d'utilisation de ceux-ci pour réguler l'expression génique. Les effecteurs de transcription ciblés peuvent comporter (i) un domaine de liaison à l'ADN de méganucléase n'ayant pas d'activité de clivage d'endonucléase qui se lie à un site de reconnaissance cible, et (ii) un domaine effecteur de transcription.
Jantz Derek
Nicholson Michael G.
Smith James Jefferson
Mbm Intellectual Property Law Llp
Precision Biosciences Inc.
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