Fusion peptide therapeutic compositions

Details Fusion peptide therapeutic compositions Fusion peptide therapeutic compositions

A - Human Necessities

61

K

A61K 38/16 (2006.01) C07K 14/78 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2663047

Therapeutic compositions containing fusion proteins (FPs) including elastin-like peptides (ELPs) and peptide active therapeutic agents, and methods of making and using such compositions and fusion proteins. Therapeutic compositions of such type enable improved efficacy of the peptide active therapeutic agent to be achieved, in relation to the peptide active therapeutic agent alone. Enhanced efficacy of the peptide active therapeutic agent in the therapeutic composition may include improved solubility, bioavailability, bio-unavailability, half-life, etc., as compared to corresponding compositions containing the same peptide active therapeutic agent without associated ELPs.

Compositions thérapeutiques contenant des protéines de fusion (FP) comprenant des peptides de type élastine (ELP) et des agents thérapeutiques actifs peptidiques, et procédés de fabrication et d'utilisation de telles compositions, et protéines de fusion. Les compositions thérapeutiques de ce type permettent d'obtenir une efficacité améliorée de l'agent thérapeutique actif peptidique, comparativement à l'agent thérapeutique actif peptidique seul. L'efficacité améliorée de l'agent thérapeutique actif peptidique dans la composition thérapeutique peut comprendre la solubilité, la bio-disponibilité, la bio-indisponibilité, la demie-vie améliorées, etc., comparativement aux compositions correspondantes contenant le même agent thérapeutique actif peptidique sans ELP associé.

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