Fusion peptides comprising a peptide ligand domain and a...

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 19/00 (2006.01) C07K 14/705 (2006.01) C07K 14/71 (2006.01) C07K 14/745 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2377731

The invention provides novel hybrid molecules comprising a peptide ligand domain which functions to bind a predetermined target molecule and a multimerization domain such as an immunoglobulin constant region domain or a leucine zipper. The hybrid molecules optionally include an additional functional moiety such as an enzyme moiety or a cytotoxic moiety. In preferred embodiments, the hybrid molecules have improved pharmacokinetic or pharmacological properties. The invention further provides for the research, diagnostic and therapeutic use of the hybrid molecules and includes compositions such as pharmaceutical compositions comprising the hybrid molecules.

La présente invention concerne des molécules hybrides comprenant un domaine ligand peptide, dont la fonction est de se lier à une molécule cible prédéterminée, ainsi qu'un domaine de multimérisation, tel qu'un domaine de région constante d'immunoglobine ou un domaine de type fermeture éclair à leucine. Les molécules hybrides comprennent éventuellement un entité fonctionnelle supplémentaire telle qu'une entité enzyme ou cytotoxique. Dans des réalisations préférées, les molécules hybrides présentent des propriétés pharmacocinétiques ou pharmacologiques améliorées. L'invention concerne aussi la recherche, le diagnostic et l'utilisation thérapeutique des molécules hybrides ainsi que des compositions, telles que des compositions pharmaceutiques, qui contiennent ces molécules.

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