Fusion polypeptides, and use thereof in antivascular tumor...

Details Fusion polypeptides, and use thereof in antivascular tumor... Fusion polypeptides, and use thereof in antivascular tumor...

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) A61K 38/36 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2535856

Disclosed is a fusion polypeptide comprising a) a peptide of 3 to 30 amino acids, which allows selective binding of the fusion polypeptide to tumor vessel endothelial cells, and b) the tissue factor TF or a fragment thereof, the tissue factor and the fragment being characterized by being able to activate coagulation when the fusion polypeptide binds to tumor vessel endothelial cells. Peptides a) and b) are coupled to each other directly or via a linker comprising up to 15 amino acids while the peptide which allows selective binding of the fusion polypeptide to tumor vessel endothelial cells is coupled to the C terminal of the peptide that is able to activate coagulation when the fusion polypeptide binds to tumor vessel endothelial cells.

L'invention concerne un polypeptide de fusion comprenant : a) un peptide de 3 à 30 aminoacides, permettant une liaison sélective du polypeptide de fusion sur des cellules endothéliales vasculaires tumorales ; et b) le facteur de tissu (Tissue Factor), ou un fragment de celui-ci, le facteur de tissu et le fragment étant caractérisés en ce qu'ils peuvent activer la coagulation sanguine lors de la liaison du polypeptide de fusion sur les cellules endothéliales vasculaires tumorales. Les peptides a) et b) sont couplés entre eux, soit directement, soit par l'intermédiaire d'un lieur, avec jusqu'à 15 aminoacides, et le peptide qui permet une liaison sélective du polypeptide de fusion sur les cellules endothéliales vasculaires tumorales, est couplé au C terminal du peptide, lequel peut activer la coagulation sanguine lors de la liaison dudit polypeptide de fusion sur les cellules endothéliales vasculaires tumorales.

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