Fusion protein capable of degrading amyloid beta peptide

Details Fusion protein capable of degrading amyloid beta peptide Fusion protein capable of degrading amyloid beta peptide

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/48 (2006.01) A61P 25/28 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2681404

The present invention relates fusion proteins and their use in enzymatic treatment of Alzheimer's disease patients. Said fusion protein has the formula M-A, capable of degrading amyloid beta peptide at one or more cleavage sites in its amino acid sequence, wherein M is a protein componentthat prolongs the half-life of the fusion protein, and A is a protein component that cleaves the amyloid beta peptide.

L'invention concerne des protéines de fusion et leur utilisation dans le traitement enzymatique des patients souffrant de la maladie d'Alzheimer. La protéine de fusion a la formule M-A, capable de dégrader le peptide bêta-amyloïde à un ou plusieurs sites de clivage dans sa séquence d'acides aminés, M étant un composant de type protéine qui prolonge la demi-vie de la protéine de fusion, et A étant un composant de type protéine qui clive le peptide bêta-amyloïde.

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