Fusion protein comprising a bh3-domain of a bh3-only protein

Details Fusion protein comprising a bh3-domain of a bh3-only protein Fusion protein comprising a bh3-domain of a bh3-only protein

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2590512

This invention relates to a fusion protein comprising at least one first portion (I) comprising a trafficking sequence and at least one second portion (II) comprising a full-length or partial BH3-domain sequence of a BH3-only protein, said fusion protein comprising D-enantiomeric amino acids in retro- inverso order in its portion (I). Furthermore, the invention relates to pharmaceutical compositions containing said fusion protein as well as to the use of said fusion protein.

L'invention concerne une protéine de fusion comprenant au moins une première partie (I) possédant une séquence de trafic et au moins une deuxième partie (II) comprenant une séquence totale ou partielle du domaine BH3 d'une protéine BH3 seulement, ladite protéine de fusion étant composée d'acides aminés D-énantiomères en ordre rétro-inversé dans sa partie (I). Elle concerne également des compositions pharmaceutiques contenant ladite protéine de fusion, ainsi que l'utilisation de cette dernière.

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