Fusion protein delivery system and uses thereof

Details Fusion protein delivery system and uses thereof Fusion protein delivery system and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) C07K 14/15 (2006.01) C12N 5/10 (2006.01) C12N 15/62 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2394261

The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag- pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.

L'invention concerne une composition de matière renfermant un ADN codant pour une protéine virale Vpx fusionnée à un ADN codant pour une protéine. Dans un autre mode de réalisation, l'invention concerne une composition de matière renfermant un ADN codant pour une protéine Vpr fusionnée à un ADN codant pour une protéine. L'invention concerne également un ADN, des vecteurs et des procédés permettant d'exprimer un gène pol lentiviral in trans, indépendant du gène gag-pol lentiviral. Un élément de transduction génique est éventuellement diffusé à un vecteur lentiviral conformément à la présente invention. L'invention concerne en outre divers procédés de diffusion d'une molécule inhibitrice de virus à une cible dans un animal. L'invention concerne finalement une composition pharmaceutique.

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