Fusion protein for prodrug activation

Details Fusion protein for prodrug activation Fusion protein for prodrug activation

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 47/48 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) C12N 9/00 (2006.01) C12N 15/13 (2006.01) C12N 15/52 (2006.01) C12N 15/62 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2107513

The invention relates to compounds which contain an antigen binding region which is bound to at least one enzyme which is able to metabolize a compound (prodrug) which has little or no cytotoxicity to a cytotoxic compound (drug), where the antigen. binding region is composed of a single polypeptide chain. It is advantageous for covalently bonded carbohydrates to be present on the polypeptide chain.

L'invention concerne des composés qui contiennent une région de liaison antigénique qui est liée à au moins une enzyme qui a la capacité de métaboliser un composé de précurseur de médicament (prodrogue), qui a peu ou pas de cytotoxicité à un composé cytotoxique (médicament), où la région de liaison antigénique est composée d'une seule chaîne polypeptidique. Il est avantageux pour les glucides liés de manière covalente à la chaîne polypeptidique.

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