Fusion protein of collagen-binding domain and parathyroid...

Details Fusion protein of collagen-binding domain and parathyroid... Fusion protein of collagen-binding domain and parathyroid...

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/29 (2006.01) C07K 14/33 (2006.01) C07K 14/635 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2683862

Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen- binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy. Pharmaceutical agents comprising a collagen-binding polypeptide segment linked to a non-peptidyl PTH/PTHrP receptor agonist or antagonist are also presented.

L'invention concerne des protéines de fusion contenant des fragments d'agoniste ou d'antagoniste actif d'hormone parathyroïdienne (PTH) et des peptides associés à l'hormone parathyroïdienne (PTHrP) couplés à un domaine de liaison au collagène. Les protéines de fusion peuvent être utilisées pour favoriser la croissance osseuse, la croissance capillaire, pour prévenir les métastases osseuses cancéreuses, pour stimuler la reconstitution immunitaire avec une greffe de cellules souches de moelle osseuse, pour favoriser la mobilisation des cellules souches de moelle osseuse pour le recueil de cellules souches autologues pour greffe et pour traiter l'ostéodystrophie rénale. L'invention concerne également des agents pharmaceutiques comprenant un segment de polypeptide se liant au collagène lié à un agoniste ou antagoniste du récepteur de PTH/PTHrP non peptidyle.

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