Fusion protein of hiv regulatory/accessory proteins

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/48 (2006.01) A61K 39/21 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01) C12N 15/62 (2006.01) C12N 15/863 (2006.01)

Patent

CA 2483640

The invention relates to fusion proteins comprising the amino acid sequence of at least four HIV proteins selected from Vif, Vpr, Vpu, Rev, Tat and Nef or derivatives of the amino acid sequence of one or more of said proteins, wherein the fusion protein is not processed to individual HIV proteins having the natural N and C termini. The invention further concerns nucleic acids encoding said proteins, vectors comprising said nucleic acids, and methods for producing said proteins. The fusion protein, nucleic acids and vectors are usable as vaccines for the at least partial prophylaxis against HIV infections.

La présente invention a trait à des protéines hybrides comportant une séquence d'acides aminés d'au moins quatre protéines de VIH choisies parmi Vif, Vpr, Vpu, Rev, Tat et Nef ou des dérivés de la séquence d'acides aminés d'une ou de plusieurs desdites protéines, dans lesquelles la protéine hybride n'est pas traitée à des protéines individuelles de VIH présentant les extrémités naturelles N et C. L'invention a trait également à des acides nucléiques codant pour lesdites protéines, des vecteurs comprenant lesdites acides nucléiques, et des procédés de production desdites protéines. La protéine hybride, les acides nucléiques et les vecteurs sont utilisables pour la prophylaxie au moins partielle des infections dues au VIH.

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