Fusion protein of porcine reproductive and respiratory...

Details Fusion protein of porcine reproductive and respiratory... Fusion protein of porcine reproductive and respiratory...

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 39/12 (2006.01) A61K 47/48 (2006.01) C07K 14/08 (2006.01) C07K 14/21 (2006.01) C12N 15/31 (2006.01) C12N 15/40 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2572555

The present invention provides a PRRSV subunit vaccine comprising a fusion protein having neutralization titers evoked, PE-PQGAB-K3, which comprises a chimeric polypeptide containing N-terminal portions of PRRSV ORF5 and ORF6 structure proteins; a portion of Pseudomonas exotoxin A binding and translocation domain; and a carboxyl terminal domain containing KDEL-KDEL-KDEL(K3) sequence. Less inflammation of PE-PQGAB-K3 vaccine group in their lungs post being PRRSV challenged indicates that PQGAB without an antigen-specific allergy effect. Importantly, PE-PQGAB-K3 vaccine presents a good protection against PRRSV infection than control groups in pig challenged experiment.

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