Fusion protein vaccine

Details Fusion protein vaccine Fusion protein vaccine

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/09 (2006.01) A61P 31/04 (2006.01) C07K 14/315 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2684494

The present invention relates to the fields of microbiology and vaccine technology, and concerns the development of a vaccine capable of conferring immunity to group B Streptococcus infections. More particularly, the present invention relates to a novel fusion protein, comprising N-terminal region fragments of group B Streptococcus surface proteins, which confers immunity to invasive strains of the group B Streptococcus. It further pertains to an isolated nucleotide sequence encoding said fusion protein; a vector; a host cell; a vaccine; and a method for preventing or treating a group B Streptococcus infection.

La présente invention concerne les domaines de la microbiologie et de la technologie des vaccins ainsi que le développement d'un vaccin capable de conférer une immunité aux infections dues au Streptocoque du groupe B. Plus particulièrement, la présente invention concerne une nouvelle protéine de fusion, comportant les fragments de région N. terminale de protéines de surface de Streptocoque du groupe B, qui confère une immunité à des souches invasives du Streptocoque du groupe B. L'invention concerne en outre une séquence de nucléotides isolés codant ladite protéine de fusion; un vecteur; une cellule hôte; un vaccin et un procédé pour prévenir ou traiter une infection due au Streptocoque du groupe B.

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