Fusion protein with directioning of vaccinal antigens toward...

Details Fusion protein with directioning of vaccinal antigens toward... Fusion protein with directioning of vaccinal antigens toward...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A01H 5/00 (2006.01) A61K 39/12 (2006.01) A61K 39/23 (2006.01) A61P 37/04 (2006.01) C07K 14/015 (2006.01) C07K 14/18 (2006.01) C07K 16/28 (2006.01) C12N 15/82 (2006.01)

Patent

CA 2717997

Fusion protein with directioning of vaccinal antigens toward antigen--presenting cells and the applications thereof. This invention relates to a gene construct that comprises, operatively bound, at least one nucleotide sequence (A) that encodes a polypeptide with SEQ ID NO: 1, which has a region that recognises the .beta. chain of the class-II DR antigen present on the surface of antigen-presenting cells; and one nucleotide sequence (B) that encodes a vaccinal antigen of interest. Moreover, this invention relates to recombinant vectors useful for the expression of the gene construct of the invention, transgenic cells and plants transformed or transfected with said vectors, fusion proteins encoded by the gene construct of the invention and vaccines that comprise said fusion proteins.

Proteína de fusión con direccionamiento de antígenos vacunales a células presentadoras de antígeno y sus aplicaciones. La presente invención se relaciona con una construcción génica que comprende operativamente unidas al menos una secuencia nucleotídica (A) que codifica para un polipéptido de SEQ ID NO: 1 que presenta una región que reconoce a la cadena ß del antígeno DR de clase II presente en la superficie de las células presentadoras de antígeno; y una secuencia nucleotídica (B) que codifica para un antígeno vacunal de interés. Además, la presente invención se refiere a vectores recombinantes útiles para la expresión de la construcción génica de la invención, células y plantas transgénicas transformadas o transfectadas con dichos vectores, proteínas de fusión codificadas por la construcción génica de la invención y vacunas que comprendan dichas proteínas de fusión.

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