Fusion proteins

Details Fusion proteins Fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 47/48 (2006.01) C07K 1/22 (2006.01)

Patent

CA 2342970

The Rho family GTPases regulate axon growth and regeneration. Inactivation of Rho with C3, a toxin from Closteridium botulinum, can stimulate regeneration and sprouting of injured axons. The present invention provides novel chimeric C3-like Rho antagonists. These new antagonists are a significant improvement over C3 compounds because they are 3- 4 orders of magnitude more potent to stimulate axon growth on inhibitory substrates than recombinant C3. The invention further provides evidence that these compounds promote repair when applied to the injured mammalian CNS.

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