Fusion proteins

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2526169

The invention provides active therapeutic peptides fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half-life, reduced half antibody formation, and reduced effector activity, while not being immunogenic. The fusion proteins are useful in treating human diseases as well as a variety of other conditions or disorders.

L'invention porte sur des peptides thérapeutiques actifs fusionnés à des dérivés de l'IgG4-Fc spécifique. Ces protéines de fusion ont une demi-vie accrue, une formation réduite de demi-anticorps et une activité d'effecteur réduite, sans être immunogènes. Les protéines de fusion sont utiles dans le traitement de pathologies humaines, ainsi que dans une différentes autres pathologies ou troubles.

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