C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/415 (2006.01) A61K 39/36 (2006.01) C12N 15/29 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2558660
The present invention relates to fusion proteins comprising different allergens of the ns-LTPs family, and their use in the prevention and the treatment of allergic symptoms associated to said allergens. In particular, fusion proteins in the form of heterodimers comprising the major allergens of Parietaria judaica, Par 1 and Parj 2, are described. Methods of preparation of the fusion proteins by expression in genetically modified host cells and pharmaceutical compositions comprising said fusion proteins are described as well.
La présente invention concerne des protéines de fusion contenant divers allergènes de la famille ns-LTPs ainsi que leur utilisation pour la prévention et le traitement de symptômes allergiques associés auxdits allergènes. L'invention concerne en particulier des protéines de fusion sous forme d'hétérodimères cmprenant les principaux allergènes de Parietaria judaica, Par 1 et Parj2. Sont également décrites des méthodes de préparation de ces protéines de fusion par expression dans des cellules hôtes génétiquement modifiées ainsi que des compositions pharmaceutiques contenant lesdites protéines de fusion.
Bonura Angela
Colombo Paolo
Geraci Domenico
Consiglio Nazionale Delle Ricerche
Fetherstonhaugh & Co.
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