Fusion proteins of immunopotentiating activity

Details Fusion proteins of immunopotentiating activity Fusion proteins of immunopotentiating activity

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/02 (2006.01) C07K 19/00 (2006.01) C12N 15/31 (2006.01)

Patent

CA 2168914

A DNA-sequence comprising a first sequence coding for a native or mutant subunit of a bacterial toxin that confers enzymatic ADP-ribosylating activity, and a second sequence coding for a peptide such that the resulting fusion protein is in possession of water solubility and capability of targeting the fusion protein to a specific cell receptor different from receptors binding to the native toxin, thereby mediating intracellular uptake of at least said subunit; fusion proteins coded for by such DNA-sequence; compositions for use in improving immune functions; and recombinant expression vectors and transformed bacterial cells containing such DNA-sequence.

Séquence d'ADN comprenant une première séquence codant une sous-unité native ou mutante d'une toxine bactérienne qui confère une activité enzymatique ADP - ribosyl transférase ainsi qu'une seconde séquence codant un peptide de manière que la protéine hybride résultante soit hydrosoluble et capable de cibler un récepteur cellulaire différent des récepteurs où se fixe la toxine native, permettant ainsi la captation intracellulaire à tout le moins de la sous-unité mentionnée; protéines hybrides codées par une telle séquence d'ADN; compositions servant à améliorer les fonctions immunitaires; et vecteurs d'expression recombinants et cellules transformées de bactéries qui contiennent cette séquence d'ADN.

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