Fusion proteins of interferon alpha muteins with improved...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/21 (2006.01) A61K 38/21 (2006.01) C07K 14/56 (2006.01)

Patent

CA 2516293

The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.

La présente invention concerne l'interféron-alpha humain et, en èparticulier des formes modifiées d'interféron-alpha 2 aux propriétés améliorées. Ces protéines améliorées contiennent des substitutions d'acides aminés à des positions spécifiquesqui confèrent une activité relative accrue dans des dosages biologiques. Cette invention concerne aussi un interféron-alpha modifié avec une activité biologique améliorée concomitante avec un potentiel immunogéne réduit dans la protéine. Ces protéines améliorées sont destinées à une utilisation thérapeutique dans le traitement de maladies humaines.

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