C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 19/00 (2006.01) A61K 39/04 (2006.01) A61P 31/06 (2006.01) C07K 14/35 (2006.01) C12P 21/02 (2006.01) C12N 15/31 (2006.01) C12N 15/62 (2006.01)
Patent
CA 2326598
The present invention relates to fusion proteins containing at least two Mycobacterium tuberculosis antigens. In particular, it relates to bi-fusion proteins which contain two individual M. tuberculosis antigens, tri-fusion proteins which contain three M. tuberculosis antigens, tetra-fusion proteins which contain four M. tuberculosis antigens, and penta-fusion proteins which contain five M. tuberculosis antigens, and methods for their use in the diagnosis, treatment and prevention of tuberculosis infection.
La présente invention concerne des protéines hybrides renfermant au moins deux antigènes de Mycobacterium tuberculosis. Plus particulièrement, elle s'applique à des protéines bihybrides renfermant deux antigènes distincts de M. tuberculosis, à des protéines trihybrides renfermant trois antigènes distincts de M. tuberculosis, à des protéines tétrahybrides renfermant quatre antigènes distincts de M. tuberculosis et à des protéines pentahybrides renfermant cinq antigènes distincts de M. tuberculosis. L'invention concerne également des techniques d'utilisation de ces protéines pour le diagnostic, le traitement et la prévention d'infections tuberculeuses.
Alderson Mark
Campos-Neto Antonio
Skeiky Yasir A.w.
Corixa Corporation
Gowling Lafleur Henderson Llp
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