C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C12N 15/67 (2006.01)
Patent
CA 2749571
The invention relates to fusion proteins comprising an amino acid sequence corresponding to an H fragment or an amino acid sequence corresponding to a calcium binding protein excreted-secreted by the adult worm of Fasciola hepatica, namely the proteins Fh8 and Fh22, followed by an amino acid sequence corresponding to an unrelated protein fragment or protein, and a process for the preparation thereof and their use in recombinant protein expression systems.
L'invention concerne des protéines de fusion comprenant une séquence d'acides aminés correspondant à un fragment H ou une séquence d'acides aminés correspondant à une protéine de liaison au calcium excrétée/sécrétée par le ver adulte de Fasciola hepatica, notamment les protéines Fh8 et Fh22, suivie d'une séquence d'acides aminés correspondant à une protéine ou un fragment protéique non associé. L'invention concerne également un procédé pour leur préparation et leur utilisation dans des systèmes d'expression de protéines recombinantes.
Da Silva Almeida Andre Augusto
Marques Da Costa Sofia Judite
Oliveira Castro Antonio Manuel
Pereira Da Conceicao Maria Antonia
Escola Superior Agraria de Coimbra
Hitag - Biotechnology Lda.
Moffat & Co.
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