C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2640066
A method for preparing recombinant fusion proteins that comprise at least one natural junction is described. Fusion proteins that contain at least one natural junction have reduced potential for immunogenicity, improved stability, reduced tendency to aggregate, improved expression and/or improved production yields relative to conventional fusion proteins. Novel fusion proteins that comprise at least one natural junction, compositions comprising the fusion proteins and methods of using the proteins are also disclosed.
L'invention concerne un procédé de préparation de protéines de fusion recombinantes qui comprennent au moins une jonction naturelle. Des protéines de fusion contenant au moins une jonction naturelle présentent un potentiel immunogène réduit, une stabilité améliorée, une tendance réduite à s'agréger, une expression améliorée et/ou des rendements de production améliorés par rapport aux protéines de fusion classiques. L'invention concerne en outre des protéines de fusion qui comprennent au moins une jonction naturelle, des compositions comprenant ces protéines de fusion, ainsi que des procédés d'utilisation des protéines.
Domantis Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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