C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01) C07K 14/21 (2006.01) C07K 14/33 (2006.01) C07K 14/34 (2006.01) C12N 5/00 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2392208
This invention relates to compositions and methods for the specific inhibition of protein synthesis in neuronal cells leading to neuronal cell death. More specifically, the invention relates to hybrid protein molecules that show high specificity for, and increased cytotoxicity in, neuronal cells. Such hybrid molecules are useful in a variety of conditions where localized inhibition of neuronal cell function is desirable.
L'invention concerne des compositions et des procédés qui permettent d'inhiber spécifiquement la synthèse de protéines dans des cellules neuronales, entraînant ainsi la mort des cellules neuronales. Plus spécifiquement, l'invention concerne des molécules de protéines hybrides qui présentent une grande spécificité à l'égard des cellules neuronales et une cytotoxicité accrue dans ces cellules. Ces molécules hybrides sont utiles dans diverses affections nécessitant une inhibition localisée de la fonction des cellules neuronales..
Brown Robert H. Jr.
Francis Jonathan W.
Murphy John R.
Oyler George A.
Vanderspek Johanna C.
Boston Medical Center Corporation
Smart & Biggar
The General Hospital Corporation
University Of Maryland Baltimore
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