Fusion proteins with cleavable spacers and uses thereof

Details Fusion proteins with cleavable spacers and uses thereof Fusion proteins with cleavable spacers and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A01N 37/18 (2006.01) A61K 47/48 (2006.01) C07K 14/535 (2006.01) C07K 14/79 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2682569

A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also disclosed are methods of producing the polypeptide and delivering the protein domains into a cell.

L'invention concerne un polypeptide comportant un premier domaine protéinique, un second domaine protéinique et une séquence d'espacement dithiocyclopeptide contenant au moins un site de reconnaissance de protéase, où le dithiocyclopeptide est exogène par rapport au premier ou au second domaine protéinique, et où les premier et second domaines protéiniques sont liés de manière fonctionnelle par le dithiocyclopeptide. Des procédés de production du polypeptide et de distribution des domaines protéiniques dans une cellule sont également décrits.

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