Fusions of cytokines and tumor targeting proteins

Details Fusions of cytokines and tumor targeting proteins Fusions of cytokines and tumor targeting proteins

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/17 (2006.01) C07K 14/52 (2006.01) C07K 14/525 (2006.01) C07K 14/57 (2006.01) C07K 14/705 (2006.01) C07K 16/30 (2006.01)

Patent

CA 2484425

A conjugate of a cytokine and a tumor targeting moiety (TTM) with the provisos that when cytokine is TNF-.alpha., TNF-.beta. or IFN-.gamma., the TTM is other than a CD13 ligant; when the cytokine is IL-12, the TTM is other than an antiboy to fibronectin; when the cytokine is TNF, the TTM is other than an antibody to the transferrin receptor; and when the cytokine is TNF, IFN- .gamma. or IL-2 the antibody is other than an antibody to the TAG72 antigen.

La présente invention concerne un conjugué d'une cytokine et d'un fragment de ciblage tumoral (TTM) à condition que lorsque la cytokine est TNF-.alpha., TNF-.beta. ou INF-.gamma., le TTM est autre qu'un ligand CD13 ; lorsque la cytokine est IL-12, le TTM est autre qu'un anticorps dirigé contre la fibronectine ; lorsque la cytokine est TNF, le TTM est autre qu'un anticorps dirigé contre le récepteur de la transferrine ; et lorsque la cytokine est TNF, INF-.gamma. ou IL-2, l'anticorps est autre qu'un anticorps dirigé contre l'antigène TAG72.

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