Fvii or fviia variants

Details Fvii or fviia variants Fvii or fviia variants

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2519873

Variants of FVII or FVIIa comprising at least one amino acid modification in position 196, 237 or 341 relative to hFVII or hFVIIa. The variants exhibit an increased clotting activity, i.e. reduced clotting time, compared to rhFVIIa.

La présente invention se rapporte à des variants de FVII ou FVIIa comportant au moins une modification d'acide aminé en position 196, 237 ou 341 relativement à hFVII ou hFVIIa. Ces variants présentent une activité de coagulation accrue, par exemple un temps de coagulation réduit en comparaison de rhFVIIa.

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