Fvii or fviia variants having increased clotting activity

Details Fvii or fviia variants having increased clotting activity Fvii or fviia variants having increased clotting activity

C - Chemistry, Metallurgy

07

K

C07K 14/745 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2502162

The present invention relates to novel Factor VII or VIIa variants comprising a substitution in at least one position selected from the group consisting of L39, 142, S43, K62, L65, F71, E82 and F275, which are positions involved in tissue factor binding. Such variants exhibit increased clotting activity as compared to human wild-type Factor VIIa. The present invention also relates to use of such Factor VII or VIIa variants in therapy, in particular for the treatment of a variety of coagulation-related disorders.

La présente invention concerne de nouveaux variants du facteur VII ou VIIa qui comprennent une substitution dans au moins une position sélectionnée dans le groupe formé par: L39, 142, S43, K62, L65, F71, E82 et F275. Ces variants présentent une activité de coagulation accrue comparativement au facteur VIIa de type sauvage humain. La présente invention se rapporte également à l'utilisation de ces variants du facteur VII ou VIIa, en thérapie, notamment pour le traitement de divers troubles liés à la coagulation.

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