Fviii peptides and their use in tolerising haemophiliacs

Details Fviii peptides and their use in tolerising haemophiliacs Fviii peptides and their use in tolerising haemophiliacs

C - Chemistry, Metallurgy

07

K

C07K 14/755 (2006.01) A61K 38/37 (2006.01)

Patent

CA 2707559

The present invention provides a peptide comprising a core residue sequence derivable from human FVIII which peptide is capable of binding to an MHC class II molecule without further antigen processing. The present invention also relates to the use of such peptides for the prevention or suppression of inhibitor antibody formation in haemophilia A and/or acquired haemophilia.

Cette invention concerne un peptide comprenant une séquence résiduelle centrale pouvant être dérivée du facteur humain FVIII, ledit peptide étant capable de se lier à une molécule de classe II du CMH sans nécessiter d'autre traitement de l'antigène. Cette invention concerne également l'utilisation de ces peptides dans la prévention ou la suppression de la formation d'anticorps des inhibiteurs dans l'hémophilie A et/ou l'hémophilie acquise.

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