Fzd2 modulators in the treatment of alopecia

Details Fzd2 modulators in the treatment of alopecia Fzd2 modulators in the treatment of alopecia

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2737993

The invention relates to an in vitro method for screening candidate compounds for the preventive or curative treatment of alopecia, said method comprising the determination of the capacity of a compound to modulate the expression or the activity of a Frizzled 2 (FZD2) transmembrane receptor, and the use of modulators of the expression or the activity of said transmembrane receptor for the treatment of alopecia. The invention also relates to methods for the in vitro diagnosis or prognosis of said pathology

L'invention concerne une méthode in vitro de criblage de composés candidats pour le traitement préventif ou curatif de l'alopécie, comprenant la détermination de la capacité d'un composé à moduler l'expression ou l'activité du récepteur transmembranaire Frizzled 2 (FZD2), ainsi que l'utilisation de modulateurs de l'expression ou de l'activité de ce récepteur transmembranaire pour le traitement de l'alopécie. L'invention concerne aussi des méthodes de diagnostic ou pronostic in vitro de cette pathologie.

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