G-csf analog compositions and methods

Details G-csf analog compositions and methods G-csf analog compositions and methods

C - Chemistry, Metallurgy

12

N

C12N 5/02 (2006.01) C12N 5/078 (2010.01) A61K 38/19 (2006.01) C07K 14/535 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2421760

The present invention relates to granulocyte colony stimulating factor ("G- CSF") polypeptide analog compositions. The concept detailed herein provides methods for screening G-CSF analogs, designed with one or more substitutions to amino acids, and selecting analogs for use G-CSF replacements or antagonists, and may be generalized beyond G-CSF analogs as well. In addition, pharmaceutical compositions and methods of use are provided for analogs so selected.

La présente invention se rapporte à des compositions d'analogues polypeptidiques du facteur stimulant les colonies de granulocytes ("G-CSF). L'invention se rapporte notamment à des procédés de criblage de ces analogues du G-CSF, conçus avec une ou plusieurs substitutions d'acide aminé, et de sélection d'analogues en vue de leur utilisation en tant qu'élément de remplacement ou antagoniste du G-CSF. Le concept de cette invention peut être généralisé au-delà des analogues du G-CSF. En outre, cette invention se rapporte à des compositions pharmaceutiques et à des procédés d'utilisation associés aux analogues ainsi sélectionnés.

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