G-csf analog compositions and methods

C - Chemistry – Metallurgy – 07 – K

Patent

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C07K 14/535 (2006.01) A61K 38/19 (2006.01) C12N 15/27 (2006.01)

Patent

CA 2381489

Provided herein are granulocyte colony stimulating factor ("G-CSF") analogs, compositions containing such analogs, and related compositions. In another aspect, provided herein are nucleic acids encoding the present analogs or related nucleic acids, related host cells and vectors. In yet another aspect, provided herein are computer programs and apparatuses for expressing the three dimensional structure of G-CSF and analogs thereof. In another aspect, provided herein are methods for rationally designing G-CSF analogs and related compositions. In yet another aspect, provided herein are methods for treatment using the present G-CSF analogs.

Divulgation d'analogues du facteur stimulant les colonies de granulocytes (« G-CSF »), de compositions contenant ces analogues et de compositions connexes. Selon un autre aspect, des acides nucléiques codant pour les analogues actuels ou des acides nucléiques connexes, des cellules hôtes apparentées et des vecteurs sont également dévoilés. Sous un autre aspect, des programmes informatiques et des appareils sont divulgués pour exprimer la structure tridimensionnelle du G-CSF et des analogues correspondants. Selon un autre aspect, des méthodes sont fournies pour concevoir de façon rationnelle des analogues du G-CSF et des compositions connexes. Sous un dernier aspect, des méthodes de traitement à l'aide des analogues actuels du G-CSF sont divulguées.

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